A role of metallothionein-3 in radiation-induced autophagy in glioma cells
Identifieur interne : 000226 ( an2020/Analysis ); précédent : 000225; suivant : 000227A role of metallothionein-3 in radiation-induced autophagy in glioma cells
Auteurs : Young Hyun Cho [Corée du Sud] ; Seung-Hwan Lee [Corée du Sud] ; Sook-Jeong Lee ; Ha Na Kim [Corée du Sud] ; Jae-Young Koh [Corée du Sud]Source :
- Scientific Reports [ 2045-2322 ] ; 2020.
Abstract
Although metallothionein-3 (
Url:
DOI: 10.1038/s41598-020-58237-7
PubMed: 32029749
PubMed Central: 7005189
Affiliations:
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PMC:7005189Le document en format XML
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Cho</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0533 4667</institution-id><institution-id institution-id-type="GRID">grid.267370.7</institution-id><institution>Neural Injury Research Center, Asan Institute for Life Sciences,</institution><institution>University of Ulsan College of Medicine,</institution></institution-wrap>Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0533 4667</institution-id><institution-id institution-id-type="GRID">grid.267370.7</institution-id><institution>Department of Neurosurgery, Asan Medical Center,</institution><institution>University of Ulsan College of Medicine,</institution></institution-wrap>Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Seung Hwan" sort="Lee, Seung Hwan" uniqKey="Lee S" first="Seung-Hwan" last="Lee">Seung-Hwan Lee</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0533 4667</institution-id><institution-id institution-id-type="GRID">grid.267370.7</institution-id><institution>Department of Biomedical Sciences,</institution><institution>University of Ulsan College of Medicine,</institution></institution-wrap>Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Sook Jeong" sort="Lee, Sook Jeong" uniqKey="Lee S" first="Sook-Jeong" last="Lee">Sook-Jeong Lee</name><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0470 4320</institution-id><institution-id institution-id-type="GRID">grid.411545.0</institution-id><institution>Department of Bioactive Material Science,</institution><institution>Jeonbuk National University,</institution></institution-wrap>Jeonju, Jeollabuk-do Republic of Korea</nlm:aff><wicri:noCountry code="subfield">Jeollabuk-do Republic of Korea</wicri:noCountry></affiliation></author><author><name sortKey="Kim, Ha Na" sort="Kim, Ha Na" uniqKey="Kim H" first="Ha Na" last="Kim">Ha Na Kim</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0533 4667</institution-id><institution-id institution-id-type="GRID">grid.267370.7</institution-id><institution>Neural Injury Research Center, Asan Institute for Life Sciences,</institution><institution>University of Ulsan College of Medicine,</institution></institution-wrap>Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Koh, Jae Young" sort="Koh, Jae Young" uniqKey="Koh J" first="Jae-Young" last="Koh">Jae-Young Koh</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0533 4667</institution-id><institution-id institution-id-type="GRID">grid.267370.7</institution-id><institution>Neural Injury Research Center, Asan Institute for Life Sciences,</institution><institution>University of Ulsan College of Medicine,</institution></institution-wrap>Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0533 4667</institution-id><institution-id institution-id-type="GRID">grid.267370.7</institution-id><institution>Department of Neurology, Asan Medical Center,</institution><institution>University of Ulsan College of Medicine,</institution></institution-wrap>Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Although metallothionein-3 (<italic>MT3</italic>), a brain-enriched form of metallothioneins, has been linked to Alzheimer’s disease, little is known regarding the role of <italic>MT3</italic> in glioma. As <italic>MT3</italic> plays a role in autophagy in astrocytes, here, we investigated its role in irradiated glioma cells. Irradiation increased autophagy flux in GL261 glioma cells as evidenced by increased levels of LC3-II but decreased levels of p62 (SQSTM1). Indicating that autophagy plays a cytoprotective role in glioma cell survival following irradiation, measures inhibiting autophagy flux at various steps decreased their clonogenic survival of irradiated GL261 as well as SF295 and U251 glioma cells. Knockdown of <italic>MT3</italic> with siRNA in irradiated glioma cells induced arrested autophagy, and decreased cell survival. At the same time, the accumulation of labile zinc in lysosomes was markedly attenuated by <italic>MT3</italic> knockdown. Indicating that such zinc accumulation was important in autophagy flux, chelation of zinc with tetrakis-(2-pyridylmethyl)ethylenediamine (TPEN), induced arrested autophagy in and reduced survival of GL261 cells following irradiation. Suggesting a possible mechanism for arrested autophagy, <italic>MT3</italic> knockdown and zinc chelation were found to impair lysosomal acidification. Since autophagy flux plays a cytoprotective role in irradiated glioma cells, present results suggest that <italic>MT3</italic> and zinc may be regarded as possible therapeutic targets to sensitize glioma cells to ionizing radiation therapy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Stupp, R" uniqKey="Stupp R">R Stupp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Wk" uniqKey="Wu W">WK Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dalby, Kn" uniqKey="Dalby K">KN Dalby</name></author><author><name sortKey="Tekedereli, I" uniqKey="Tekedereli I">I Tekedereli</name></author><author><name sortKey="Lopez Berestein, G" uniqKey="Lopez Berestein G">G Lopez-Berestein</name></author><author><name sortKey="Ozpolat, B" uniqKey="Ozpolat B">B Ozpolat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amaravadi, Rk" 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Armitage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bell, Sg" uniqKey="Bell S">SG Bell</name></author><author><name sortKey="Vallee, Bl" uniqKey="Vallee B">BL Vallee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobs, Vl" uniqKey="Jacobs V">VL Jacobs</name></author><author><name sortKey="Valdes, Pa" uniqKey="Valdes P">PA Valdes</name></author><author><name sortKey="Hickey, Wf" uniqKey="Hickey W">WF Hickey</name></author><author><name sortKey="De Leo, Ja" uniqKey="De Leo J">JA De Leo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koh, Jy" uniqKey="Koh J">JY Koh</name></author><author><name sortKey="Choi, Dw" uniqKey="Choi D">DW Choi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><noCountry><name sortKey="Lee, Sook Jeong" sort="Lee, Sook Jeong" uniqKey="Lee S" first="Sook-Jeong" last="Lee">Sook-Jeong Lee</name></noCountry><country name="Corée du Sud"><noRegion><name sortKey="Cho, Young Hyun" sort="Cho, Young Hyun" uniqKey="Cho Y" first="Young Hyun" last="Cho">Young Hyun Cho</name></noRegion><name sortKey="Cho, Young Hyun" sort="Cho, Young Hyun" uniqKey="Cho Y" first="Young Hyun" last="Cho">Young Hyun Cho</name><name sortKey="Kim, Ha Na" sort="Kim, Ha Na" uniqKey="Kim H" first="Ha Na" last="Kim">Ha Na Kim</name><name sortKey="Koh, Jae Young" sort="Koh, Jae Young" uniqKey="Koh J" first="Jae-Young" last="Koh">Jae-Young Koh</name><name sortKey="Koh, Jae Young" sort="Koh, Jae Young" uniqKey="Koh J" first="Jae-Young" last="Koh">Jae-Young Koh</name><name sortKey="Lee, Seung Hwan" sort="Lee, Seung Hwan" uniqKey="Lee S" first="Seung-Hwan" last="Lee">Seung-Hwan Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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